Calcium Citrate

Calcium Citrate is a calcium salt of citric acid with the chemical formula Ca3(C6H5O7)2. It is commonly used as a dietary supplement to increase calcium intake in individuals who do not consume enough calcium through their diet. Calcium citrate is also used as a pharmaceutical excipient in tablet and capsule formulations, and as a food additive in various products.

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It is a triprotic acid that can donate three protons. Calcium citrate is a white, odorless, and tasteless powder that is highly soluble in water.

The chemical symbol for calcium is Ca, while the symbol for citrate is C6H5O7. Some of the synonyms for calcium citrate include calcium 2-hydroxypropane-1,2,3-tricarboxylate, tricalcium citrate, and calcium citrate tribasic. West Bengal Chemical Industries Limited is one of the best and premium manufacturers of Calcium Citrate worldwide & caters to some well-regarded clients worldwide.

Calcium citrate has several important characteristics, such as its ability to enhance bone health, support muscle function, and aid in nerve transmission. It is also known for its mild and well-tolerated nature, making it a popular choice for individuals who have trouble digesting other forms of calcium supplements. Additionally, calcium citrate is less dependent on stomach acid for absorption, which can be beneficial for individuals with low stomach acid levels or those taking acid-reducing medications.

Molecular Formula – Ca₃(C₆H₅O₇)₂

Molecular Weight – 570.49 gm/mol

CAS No – 5785-44-4

Shelf Life – 36 months

HSN Code – 2918.1590

Packing Size – 25 kg in HDPE bag/drum

Storage Condition – Keep Well Closed, protected against light, dry and at room temperature

Additional Info – 1. Available as powder & DC grade

2. Granular in form

3. Documentations ready & available

Sl. No.	PARAMETER	SPECIFICATION
1.	Description	White free flowing micro granules, with occasional friable lumps
2.	Solubility	Insoluble in Water, Soluble in Mineral Acids.
3.	Identification	Positive for Calcium & Citrates.
4.	LOD (dry at 150°C for 4 hrs)	10.00% w/w- 13.30% w/w
5.	Fluoride	NMT 0.003%
6.	Heavy Metal	NMT 0.002%
7.	Arsenic	NMT 3 ppm
8.	Lead	NMT 0.001%
9.	Acid Insoluble Matter	NMT 0.2% w/w
10.	Assay	97.5% w/w– 100.5% w/w
Granules Flow Properties (For Information):
11.	Bulk Density: · Untapped · Tapped	NLT 0.65 g/cm³ NLT 0.75 g/cm³
12.	Compressibility Index (%)	NMT 15%
13.	Particle Size Distribution	NMT 15% passes through 85 mesh NLT 90% passes through 10 mesh
For Other Customer:
14.	Particle Size Distribution	NMT 30% passes through 85 mesh

Applications of Calcium Citrate in various industries:

Calcium citrate has a variety of applications in different fields, including:

Dietary supplement: Calcium citrate is widely used as a dietary supplement to increase calcium intake in individuals who do not consume enough calcium through their diet. It is commonly found in multivitamin and mineral supplements, as well as in standalone calcium supplements.

Pharmaceutical excipient: Calcium citrate is used as a pharmaceutical excipient in tablet and capsule formulations, as it can act as a binder, disintegrant, or filler. It can also enhance the bioavailability of certain drugs, such as tetracycline antibiotics, by forming soluble complexes with them.

Food additive: Calcium citrate is approved as a food additive in many countries, and is used in a variety of food and beverage products, such as juices, soft drinks, and candy. It can act as a buffer, emulsifier, or firming agent, depending on the application.

Cosmetics: Calcium citrate can be found in some cosmetic and personal care products, such as toothpaste and mouthwash, as it can help to strengthen teeth and promote oral health.

Industrial applications: Calcium citrate has some industrial applications, such as in the production of cheese and other dairy products, where it can act as a coagulant to help the milk proteins solidify. It is also used in the production of certain types of ceramics and as a catalyst in certain chemical reactions.

Strontium increasing calcium accessibility from calcium citrate

Abstract Strontium chloride added to aqueous suspensions of metastable calcium citrate tetrahydrate increased calcium ion activity measured electrochemically without transition of metastable tetrahydrate to stable calcium citrate hexahydrate as shown by DSC. Calcium activity increase was explained by lower solubility...

Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Crossover Clinical Trial

Abstract In hypoparathyroidism (HypoPT), calcium supplementation is virtually always required, although the disease is likely to be associated with an increased risk of nephrolithiasis. The use of calcium citrate (Ca-Cit) theoretically could have a positive impact on the nephrolithiasis risk...

Dose dependency of calcium absorption: a comparison of calcium carbonate and calcium citrate

Abstract Calcium supplementation is recommended as a prophylaxis against bone loss. This study was performed to determine the dose dependency of calcium absorption in an attempt to derive an optimum dose schedule. Using the well-described oral calcium load technique, we...

The effect of calcium citrate on bone density in the early and mid-postmenopausal period: a randomized placebo-controlled study

Abstract This placebo-controlled randomized trial was conducted to ascertain the value of calcium citrate supplementation in averting bone loss in 63 postmenopausal women, 57 of whom were early postmenopausal (five years after menopause) and six of whom were mid-postmenopausal (five...