Sodium Butyrate is a sodium salt of butyrate which has antineoplastic properties. Butyrate is a short-chain fatty acid that bonds together with zinc sites of class I and II histone deacetylases competitively (HDACs).
This bond can affect histone hyperacetylation, which can modify DNA conformation and lead to chromatin uncoiling or relaxing. It can increase chromatin accessibility to transcription-regulatory complexes that can repress cell cycle-related genes. It can also affect the proteome and gene expression pathways in body cells.
Usually, Sodium Butyrate is used in pharmaceutical drugs to help with the passive absorption of water in the colon. It can affect
cognitive function in Schizophrenia. Sodium Butyrate can also be used in food consumption as an additive to prevent colon cancer in animals.
WBCIL is one of the top leading sodium butyrate manufacturers in India that provides this pharmaceutical drug at market sodium butyrate price.
Molecular Formula – C4H7NaO2
Molecular Weight – 10.09 gm/mol
CAS No – 156-54-7
Shelf Life – 36 months
HSN Code – 2915.6010
Packing Size – 20/25 kg in HDPE bag/drum
Storage Condition – Keep Well Closed, protected against light, dry and at room temperature
|1.||Description||White free flowing powder, with occasional friable lump, odour characteristic.|
|2.||Solubility||Soluble in water|
|3.||Identification||Positive for Sodium & Butyric Acid.|
|4.||pH (of 10% solution in water)||7.0 – 11.0|
|5.||Heavy Metals (as Lead)||NMT 10 ppm|
|6.||Arsenic||NMT 3 ppm|
|7.||LOD (at 105°C till constant weight)||NMT 3.0% w/w|
|8.||Assay (On Dried Basis)||98.0% w/w – 101.0% w/w|
|Process Regulator||Sodium Butyrate works as an accelerator, activator, oxidation agent, reducing agent, etc.|
|Manufacturing||It can be used in manufacturing papers.|
|Bio Chemistry||HDAC (Histone Deacetylase Inhibitor).|
|Feed Additives||Can be used as a food additive for animals to provide nutrition. It can help to prevent Colon Cancer in animals.|
|Food||Sodium Butyrate has a high fungus-killing rate and low toxicity that can help in agriculture to produce more healthy fruits and vegetables.|
Abstract Maternal nutrition, gut microbiome composition, and metabolites derived from gut microbiota are closely related to the development of hypertension in offspring. A plethora of metabolites generated from diverse tryptophan metabolic pathways show both beneficial and harmful effects. Butyrate, one...Read more
ABSTRACT Chemically protected sodium butyrate (CSB) is a new kind of sodium butyrate. Our previous study found that 1,000 mg/kg of CSB had the potential capacity of improving growth performance and promoting early development of small intestine in broilers. This...Read more
Abstract Inflammation and fibrosis are the important pathophysiologic processes in diabetic kidney disease (DKD), which is induced by epigenetics, especially histone posttranslational modification (HPTMs). Recent reports highlighted that butyrate, one of the short-chain fatty acids (SCFAs) primarily originated from the...Read more
Abstract in English, Chinese Metabolic-associated fatty liver disease (MAFLD) has become the most common chronic liver disease affecting global public health, and its incidence rate is increasing year by year. The molecular mechanism of its pathogenesis is not yet fully...Read more
Abstract Rationale: Energy metabolism disorder is a widespread feature that exists in the early clinical stages of Alzheimer's disease (AD). Astrocyte is the most numerous and the largest glial cell in the brain. By transporting energetic fuels such as lactate...Read more
Abstract Background: Butyrate has shown anti-inflammatory and regenerative properties, providing symptomatic relief when orally supplemented in patients suffering from various colonic diseases. We investigated the effect of a colonic-delivery formulation of butyrate on the fecal microbiota of patients with inflammatory...Read more
Abstract Accumulating evidence suggests that selected microbiota-derived metabolites play a significant role in both tumor prevention and supportive treatment of cancer. Short-chain fatty acids (SCFAs), i.e., mainly acetate, proprionate, and butyrate, are one of them. Nowadays, it is known that...Read more