Sodium Butyrate

Sodium Butyrate is a sodium salt of butyrate which has antineoplastic properties. Butyrate is a short-chain fatty acid that bonds together with zinc sites of class I and II histone deacetylases competitively (HDACs).

This bond can affect histone hyperacetylation, which can modify DNA conformation and lead to chromatin uncoiling or relaxing. It can increase chromatin accessibility to transcription-regulatory complexes that can repress cell cycle-related genes. It can also affect the proteome and gene expression pathways in body cells.

India’s Leading Sodium Butyrate Supplier

Usually, Sodium Butyrate is used in pharmaceutical drugs to help with the passive absorption of water in the colon. It can affect

cognitive function in Schizophrenia. Sodium Butyrate can also be used in food consumption as an additive to prevent colon cancer in animals.

WBCIL is one of the top leading sodium butyrate manufacturers in India that provides this pharmaceutical drug at market sodium butyrate price.

Molecular Formula – C₄H₇NaO₂

Molecular Weight – 10.09 gm/mol

CAS No – 156-54-7

Shelf Life – 36 months

HSN Code – 2915.6010

Packing Size – 20/25 kg in HDPE bag/drum

Storage Condition – Keep Well Closed, protected against light, dry and at room temperature

Sl. No.	PARAMETER	SPECIFICATION
1.	Description	White free flowing powder, with occasional friable lump, odour characteristic.
2.	Solubility	Soluble in water
3.	Identification	Positive for Sodium & Butyric Acid.
4.	pH (of 10% solution in water)	7.0 – 11.0
5.	Heavy Metals (as Lead)	NMT 10 ppm
6.	Arsenic	NMT 3 ppm
7.	LOD (at 105°C till constant weight)	NMT 3.0% w/w
8.	Assay (On Dried Basis)	98.0% w/w – 101.0% w/w

Category	Description
Process Regulator	Sodium Butyrate works as an accelerator, activator, oxidation agent, reducing agent, etc.
Manufacturing	It can be used in manufacturing papers.
Bio Chemistry	HDAC (Histone Deacetylase Inhibitor).
Drugs	Used as a dietary supplement to improve passive absorption of water in the colon. Helps with memory function in an Alzheimer’s disease mouse model. Sodium Butyrate is also used as a treatment for Irritable Bowel Syndrome (IBS) & Crohn’s Disease. As well it can induce Pancreatic Progenitor formation. Works as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells. Can be used as a histone deacetylase inhibitor in breast cancer cell line MDA-MB-231.
Feed Additives	Can be used as a food additive for animals to provide nutrition. It can help to prevent Colon Cancer in animals.
Food	Sodium Butyrate has a high fungus-killing rate and low toxicity that can help in agriculture to produce more healthy fruits and vegetables.

Sodium butyrate modulates blood pressure and gut microbiota in maternal tryptophan-free diet-induced hypertension rat offspring

Abstract Maternal nutrition, gut microbiome composition, and metabolites derived from gut microbiota are closely related to the development of hypertension in offspring. A plethora of metabolites generated from diverse tryptophan metabolic pathways show both beneficial and harmful effects. Butyrate, one...

Long-term chemically protected sodium butyrate supplementation in broilers as an antibiotic alternative to dynamically modulate gut microbiota

ABSTRACT Chemically protected sodium butyrate (CSB) is a new kind of sodium butyrate. Our previous study found that 1,000 mg/kg of CSB had the potential capacity of improving growth performance and promoting early development of small intestine in broilers. This...

Sodium Butyrate Attenuates Diabetic Kidney Disease Partially via Histone Butyrylation Modification

Abstract Inflammation and fibrosis are the important pathophysiologic processes in diabetic kidney disease (DKD), which is induced by epigenetics, especially histone posttranslational modification (HPTMs). Recent reports highlighted that butyrate, one of the short-chain fatty acids (SCFAs) primarily originated from the...

Research progress of sodium butyrate in metabolic-associated fatty liver disease

Abstract in English, Chinese Metabolic-associated fatty liver disease (MAFLD) has become the most common chronic liver disease affecting global public health, and its incidence rate is increasing year by year. The molecular mechanism of its pathogenesis is not yet fully...

Sodium butyrate ameliorates the cognitive impairment of Alzheimer’s disease by regulating the metabolism of astrocytes

Abstract Rationale: Energy metabolism disorder is a widespread feature that exists in the early clinical stages of Alzheimer's disease (AD). Astrocyte is the most numerous and the largest glial cell in the brain. By transporting energetic fuels such as lactate...

Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease

Abstract Background: Butyrate has shown anti-inflammatory and regenerative properties, providing symptomatic relief when orally supplemented in patients suffering from various colonic diseases. We investigated the effect of a colonic-delivery formulation of butyrate on the fecal microbiota of patients with inflammatory...

Sodium butyrate in both prevention and supportive treatment of colorectal cancer

Abstract Accumulating evidence suggests that selected microbiota-derived metabolites play a significant role in both tumor prevention and supportive treatment of cancer. Short-chain fatty acids (SCFAs), i.e., mainly acetate, proprionate, and butyrate, are one of them. Nowadays, it is known that...