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Product Name:
Liposomal Glutathione
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Molecular Formula:
C10H17N3O6S
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Molecular Weight:
307.33 g/mol
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CAS No.:
70-18-8
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HSN Code:
29419090
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CID Code:
124886
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Shelf Life:
3 years
- USP
- Insights
- MSDS
- White Paper
USP of Liposomal Glutathione
- Mimic biological structures
- Liposomal technology ensures superior absorption and targeted delivery to cells.
- Potent Antioxidant Protection, safeguarding cells from oxidative damage.
- Enhanced Immune Support.
- Supports healthier skin by reducing inflammation and promoting collagen production.
- High encapsulation efficiency exceeding 80%.
- Improves liver detoxification
Insights Liposomal Glutathione
- Appearance: Off white dry powder
- Solubility: Water-dispersible (liposomal form)
- Stability: Highly stable under GMP storage conditions
- Formulation Type: Powder, Oral Liquid Suspension, Capsules, sachets
- Particle Size: 100-220 nm
- pH: 3.0-4.0
- storage temp: 20°C
- Storage Conditions: Store in a cool, dry place, away from light
- Odor: Mild, slightly earthy odor
- Packaging: Food-safe HDPE drums, glass bottles, or sachets
MSDS of Liposomal Glutathione
Description of Liposomal Glutathione
Glutathione (GSH) is a tripeptide, cysteine, glycine, and glutamic acid, and is the most abundant endogenous antioxidant in human cells. Its core vulnerability is chemical: the active sulfhydryl group (–SH) on cysteine oxidises rapidly on exposure to gastric acid, digestive enzymes, heat, and light. Conventional oral glutathione is broken down into its constituent amino acids before reaching the bloodstream, delivering negligible intracellular GSH elevation. Liposomal encapsulation solves this at the structural level.
WBCIL, a WHO-GMP certified liposomal glutathione manufacturer, engineers reduced glutathione within a phospholipid bilayer that mimics human cell membranes. Liposomal delivery preserves reduced glutathione integrity and supports efficient delivery at the cellular level.
Application of Liposomal Glutathione
- Antioxidant Therapy: Protects cells from oxidative stress in various diseases, including: Neurodegenerative diseases (Alzheimer’s, Parkinson’s), Liver diseases (hepatitis, cirrhosis), Certain cancers, HIV/AIDS, and Cardiovascular diseases
- Immune Support: Boosts immune function in immunocompromised individuals, those with chronic infections, and during recovery from illness.
- Anti-aging: May slow down aging processes by reducing oxidative damage to cells and tissues.
- Neuroprotection: May protect neurons from damage in neurodegenerative diseases and stroke.
- Detoxification: Supports liver detoxification and may aid in the removal of heavy metals.
- Offers some protection against radiation damage.
Used in various cosmetic products, such as creams, serums, and lotions.
- Skin Brightening: Inhibits melanin production, leading to a more even skin tone. Helps fade hyperpigmentation such as age spots, melasma, and freckles.
- Anti-aging: Neutralizes free radicals that contribute to skin aging. Stimulates collagen production, improving skin firmness and reducing wrinkles. Helps protect against UV damage and photo aging.
- Improved Skin Texture: Reduces inflammation and promotes cell turnover, leading to smoother and more radiant skin.
- Antioxidant Protection: Provides a potent barrier against environmental stressors like pollution and smoke.
- Athletic Performance: Reduces exercise-induced oxidative stress and improve recovery.
Liposomal Technology & Delivery Science
Phospholipid Architecture
82.05% Phosphatidylcholine (PC) and 10.82% Phosphatidylethanolamine (PE), yielding 93% phospholipids; >75% form uniform liposomes, ensuring consistent encapsulation efficiency, integrity, and cellular uptake.
Vesicle Engineering
Vesicles 100-220 nm; zeta −31.87 mV ensures electrostatic stability; PDI 0.084 confirms uniformity; reproducible GMP-grade batches across 50% and 90% concentrations.
Analytical Compliance
Encapsulation efficiency (EE%) via HPLC; particle characterisation by DLS; structural confirmation via FTIR and DSC. Stability under ICH Q1A/Q1B protocols, with batch-specific CoA and third-party tested documentation, and FDA, EMA, CDSCO, FSSAI-ready dossiers.
Liposomal Glutathione vs Traditional Glutathione
A five-parameter comparison demonstrating why liposomal delivery is the most effective clinically supported delivery approach for meaningful intracellular GSH elevation.
| Parameter | Liposomal Glutathione | Traditional Glutathione |
|---|---|---|
| Absorption Mechanism | Endocytosis enables direct intracellular delivery via phospholipid bilayer fusion | Passive diffusion; tripeptide is degraded into amino acids before absorption |
| Bioavailability & GSH Elevation | Plasma GSH up to 64x; 40% whole blood, 100% PBMC increase | Minimal systemic GSH increase; the majority degraded before absorption |
| Oxidative Stress Reduction | 35% reduction in plasma 8-isoprostane, validated oxidative biomarker | No measurable reduction in oxidative stress biomarkers reported |
| Immune System Activation | 400% NK cell activity; 60% lymphocyte proliferation increase, as published in studies. | Negligible impact on immune system function markers observed |
| GI Tolerability & Stability | Bilayer-protected; no sulfur taste; stable, 3-year GMP shelf life | Acid degradation, sulfur odour, poor stability, and palatability |
OEM, Private Label & Bulk Ingredient Supply
WBCIL, a WHO-GMP and cGMP certified liposomal glutathione bulk supplier, provides reduced glutathione powder, OEM dietary supplements, and private label solutions globally with CoA and regulatory-compliant documentation.
Regulatory Compliance
Manufactured under globally compliant quality systems with validated analytical characterisation and stability protocols, supported by complete regulatory documentation.
Private Labelling in 30+ Countries
Flexible MOQ from samples to multi-tonne bulk, with custom packaging and label design backed by 64+ years of pharmaceutical expertise.
Bulk Ingredient Supply for Clinics & Formulators
WHO-GMP certified liposomal glutathione with validated batch consistency and reproducible physicochemical parameters across concentrations.
Engineering Precision in WBCIL’s Liposomal Systems
Liposomal efficacy relies on structural and analytical determinants. The following characteristics define WBCIL’s formulation quality for bulk API manufacturing.
| Parameter | Ordinary Liposomes | WBCIL Liposomes |
|---|---|---|
| Phospholipid Purity | Mixed grade, unspecified PC content | 93% total phospholipids, HPLC-verified |
| Particle Uniformity | PDI often exceeds 0.5 | PDI as low as 0.084, highly uniform |
| Colloidal Stability | Zeta potential below −20 mV | Zeta potential precisely −50.40 mV |
| Encapsulation Efficiency (EE) | EE% unvalidated or undisclosed | EE% 86.38–87.3%, HPLC-confirmed |
| Manufacturing Standard | No GMP process documentation | WHO-GMP & ICH-validated |
Sourcing Liposomal Glutathione from WBCIL
- Manufacturing Legacy: 64+ years of pharmaceutical API and liposomal nutraceutical manufacturing across India’s most regulated facilities.
- Patented Science: 17 active patents, including a patented solvent-free green liposomal manufacturing process, no harsh solvents, and no thermal degradation of phospholipid integrity.
- Transparent Quality: Every batch ships with HPLC CoA, FTIR structural confirmation, DLS particle characterisation report, and ICH stability data.
- Global Reach: Trusted by 4,000+ clients, including nutraceutical OEM manufacturers, clinical formulators, and supplement companies across the USA, UK, EU, and other countries.
- Award Recognised: National IP Award 2024 winner – India’s Top MSME for Patent Filing and Commercialisation by the Ministry of Commerce & Industry.
- Certified Compliance: WHO-GMP, cGMP, ISO, HACCP, and FSSAI certified, USFDA guideline-maintained production process.
Liposomal glutathione is enclosed within a phospholipid bilayer that protects it from digestive breakdown. This improves cellular uptake and results in higher intracellular delivery than conventional glutathione forms.
Conventional glutathione shows limited intracellular delivery due to instability before systemic circulation. Liposomal delivery helps preserve the active form and supports improved intracellular availability.
Liposomal glutathione is compatible with powders, liquids, sachets, and functional nutrition formats. This enables you to develop targeted applications across wellness, beauty, and clinical nutrition segments.
High-quality liposomal glutathione typically demonstrates controlled particle size distribution, stable zeta potential, and high encapsulation efficiency for consistent delivery performance. These factors ensure consistent performance, absorption, and shelf-life across production batches.
WBCIL provides liposomal glutathione with validated process consistency, scalable manufacturing, and detailed analytical documentation supporting global formulation requirements. Its WHO-GMP-compliant manufacturing and consistent batch quality support a reliable global B2B supply.
