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L-Methylfolate
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Product Name

L-Methylfolate

Molecular Formula C20H23CaN7O6
Molecular Weight 497.5 g/mol
CAS No 151533-22-1
HSN Code 29362910
CID Code 135564391
Shelf Life 3 years - 20°C powder
USP of Products

Inadequate folate levels have been associated with specific types of anemia. Folic acid supplements are available in diverse formulations, including L-methylfolate, levomefolate, and methyltetrahydrofolate. However, L-methylfolate emerges as the most bioactive form within the body. Taking a prenatal or multivitamin with L-methylfolate is more beneficial than taking one with folic acid.

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Description of L-Methylfolate

Folate, a vital B-vitamin inherent in various dietary sources, plays a crucial role in cellular formation, particularly in the development of healthy red blood cells. Possessing superior absorption capabilities, L-methylfolate effectively enhances folate concentrations in the bloodstream.

Application of L-Methylfolate

  • Treatment of Major Depressive Disorder (MDD): Used as an adjunctive treatment to enhance the efficacy of antidepressants.
  • Management of Folate Deficiency: Essential in treating or preventing folate deficiency, particularly in individuals with genetic polymorphisms like MTHFR mutation.
  • Pregnancy and Lactation: Prescribed to pregnant women to prevent neural tube defects and other fetal developmental issues.
  • Psychiatric Disorders: Used in managing certain psychiatric conditions like schizophrenia and bipolar disorder, where folate metabolism plays a role.
  • Cardiovascular Health: Helps in reducing homocysteine levels, thereby potentially lowering the risk of heart diseases.
  • Neurological Disorders: Applied in the treatment of neuropathies and certain neurodegenerative diseases where folate metabolism is implicated.
  • Used in elderly patients or those with cognitive impairments to improve brain function and memory.
  • Alcoholism Recovery: Assists in the recovery of chronic alcoholics, where folate deficiency is often a concern.
  • Cancer Adjunct Therapy: Investigated for its role in enhancing the effectiveness of certain chemotherapeutic agents.
  • Pediatric Use: Prescribed for children with folate metabolism disorders or specific genetic conditions affecting folate usage.
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