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  • Molecular Formula:
  • Molecular Weight:
    497.5 g/mol
  • CAS No.:
  • HSN Code:
  • CID Code:
  • Shelf Life:
    3 years - 20°C powder
  • Chem Spider ID
  • UNII No.

USP of L-Methylfolate

Inadequate folate levels have been associated with specific types of anemia. Folic acid supplements are available in diverse formulations, including L-methylfolate, levomefolate, and methyltetrahydrofolate. However, L-methylfolate emerges as the most bioactive form within the body. Taking a prenatal or multivitamin with L-methylfolate is more beneficial than taking one with folic acid.

IUPAC Names of L-Methylfolate


Synonyms of L-Methylfolate

  • Levomefolate calcium
  • Calcium levomefolate
  • Levomefolinate calcium
  • L-methylfolate Calcium
  • Levomefolate (calcium)
  • L-5-mthf-ca
  • L-methylfolate-calcium
  • Levomefolate calcium
  • Calcium L-methylfolate
  • L-5-Methyltetrahydrofolate calcium
  • Calcium L-5-methyltetrahydrofolate
  • L-5-methyl tetrahydrofolic
  • (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid, calcium salt
  • (6s)-5-methyltetrahydrofolic acid calcium salt
  • Calcium N-(4-((((6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate
  • calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
  • Calciuml-5-Methyltetrahydrofolate
  • L-5-Methyletrahydrofolate calcium
  • calcium (2S)-2-(4-((((6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioate
  • calcium (2S)-2-[4-({[(6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzamido]pentanedioate
  • L-5-MTHF calcium
  • calcium (6s)-5-methyltetrahydrofolate
  • N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid calcium salt
  • Calcium L-5-Methyltetrahydrofolate
  • L-5-methyltetrahydrofolic Acid, Calcium Salt
  • 6(S)-5-methyltetrahydrofolic Acid, Calcium Salt
  • (S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioicacid,calciumsalt
  • calcium (2S)-2-{[4-({[(6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioate
  • calcium (4-((((S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate
  • calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
  • L-Glutamic acid, N-(4-((((6S)-2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1)

MSDS of L-Methylfolate

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Hazards Identification
  • Classification of the substance or mixture: Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
  • Label elements: Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
  • Other hazards: This substance/mixture contains no components considered to be either persistent, bio accumulative and toxic (PBT), or very persistent and very bio accumulative (vPvB) at levels of 0.1% or higher.
Basic Physical and Chemical Properties
  • Physical State: Solid, powder.
  • Appearance: White to yellow color powder.
  • Odor: No data available.
  • Solubility in water: Sparingly soluble in water.
Exposure Controls / Personal Protection
  • Appropriate engineering controls: Use process enclosures, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits.
  • Personal protective equipment:
    Eye/face protection:
    Safety glasses; Compatible chemical-resistant gloves; Lab coat and NIOSH approved respirator, as conditions warrant.
    Skin protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove’s outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
    Body Protection: Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
    Respiratory protection: NIOSH approved respirator, as conditions warrant.
    Control of environmental exposure: Do not let product enter drains.
Disposal Considerations
  • Waste treatment methods Product: Dispose in accordance with local, state, and federal regulations.
  • Contaminated packaging: Dispose of as unused product.
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Description of L-Methylfolate

Folate, a vital B-vitamin inherent in various dietary sources, plays a crucial role in cellular formation, particularly in the development of healthy red blood cells. Possessing superior absorption capabilities, L-methylfolate effectively enhances folate concentrations in the bloodstream.

Application of L-Methylfolate

  • Treatment of Major Depressive Disorder (MDD): Used as an adjunctive treatment to enhance the efficacy of antidepressants.
  • Management of Folate Deficiency: Essential in treating or preventing folate deficiency, particularly in individuals with genetic polymorphisms like MTHFR mutation.
  • Pregnancy and Lactation: Prescribed to pregnant women to prevent neural tube defects and other fetal developmental issues.
  • Psychiatric Disorders: Used in managing certain psychiatric conditions like schizophrenia and bipolar disorder, where folate metabolism plays a role.
  • Cardiovascular Health: Helps in reducing homocysteine levels, thereby potentially lowering the risk of heart diseases.
  • Neurological Disorders: Applied in the treatment of neuropathies and certain neurodegenerative diseases where folate metabolism is implicated.
  • Used in elderly patients or those with cognitive impairments to improve brain function and memory.
  • Alcoholism Recovery: Assists in the recovery of chronic alcoholics, where folate deficiency is often a concern.
  • Cancer Adjunct Therapy: Investigated for its role in enhancing the effectiveness of certain chemotherapeutic agents.
  • Pediatric Use: Prescribed for children with folate metabolism disorders or specific genetic conditions affecting folate usage.

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