Dimethyl fumarate | C6H8O4: Nrf2 Activator

3D Model

Product Name:
Dimethyl Fumarate
Molecular Formula:
C6H8O4
Molecular Weight:
144.12 g/mol
CAS No.:
624-49-7
HSN Code:
29171990
CID Code:
637568
Shelf Life:
3 years - 20°C powder
ATC Code (WHO)
L04AX07
DrugBank ID
DB08908
ChemSpider ID
553171
UNII No.
FO2303MNI2

USP
IUPAC Names
Synonyms

USP of Dimethyl Fumarate

Dimethyl Fumarate is used to treat relapses of multiple sclerosis, including relapsing-remitting disease, clinically isolated syndrome, and active secondary progressive disease. This medicine can decrease the number of relapses of multiple sclerosis.

IUPAC Names of Dimethyl Fumarate

dimethyl (E)-but-2-enedioate

Synonyms of Dimethyl Fumarate

Dimethyl fumarate
(E)-Dimethyl fumarate
Dimethylfumarate
Methyl fumarate
Fumaric acid, dimethyl ester
Dimethyl (E)-but-2-enedioate
Fumaric acid dimethyl ester
Boletic acid dimethyl ester
Dimethyl trans-ethylenedicarboxylate
trans-Butenedioic acid dimethyl ester
Allomaleic acid dimethyl ester
dimethyl (2E)-but-2-enedioate
trans-1,2-Ethylenedicarboxylic acid dimethyl ester
2-Butenedioic acid (E)-, dimethyl ester
Dimethylester kyseliny fumarove
(E)-but-2-enedioic acid dimethyl ester
dimethyl-fumarate
Dimethyl fumarate
2-Butenedioic acid (2E)-, dimethyl ester
UNII-FO2303MNI2
1,2-bis(methoxycarbonyl)-trans-ethylene
Dimethyl 2-butenedioate
Ethylene, 1,2-bis(methoxycarbonyl)-, trans-
Fumaric acid-dimethyl ester
2-butenedioic Acid, Dimethyl Ester, (E)-
Dimethyl (2e)-2-butenedioate
2-butenedioic acid, (2E)-, dimethyl ester
dimethyl (~{E})-but-2-enedioate
But-2-enedioic acid, dimethyl ester
2-Butenedioic acid, dimethyl ester
2-Butenedioic acid (2E)-, 1,4-dimethyl ester
Ethylene,2-bis(methoxycarbonyl)-, trans-
1,4-dimethyl but-2-enedioate
dimethyl trans-butenedioate
Dimethyl ester(E)-2-Butenedioic acid
(E)-CH3OC(O)CH=CHC(O)OCH3
1,4-dimethyl (2E)-but-2-enedioate
Dimethyl ester(2E)-2-Butenedioic acid

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Description of Dimethyl Fumarate

Multiple sclerosis affects the central nervous system. It damages nerves that send messages from the brain to other parts of human body. Dimethyl Fumarate helps to decrease the number of multiple sclerosis relapses in individuals with relapsing or remitting forms of the disease. It may not provide a cure but decrease the number of relapses.

Application of Dimethyl Fumarate

Multiple Sclerosis (MS) Treatment: Primarily used for the treatment of relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. DMF helps in reducing the frequency and severity of relapses and slowing the progression of disability.
Psoriasis Management: Effective in the treatment of moderate to severe plaque psoriasis. DMF helps in controlling the symptoms and progression of this chronic skin condition.
Anti-Inflammatory Properties: Exhibits anti-inflammatory effects, which are beneficial in treating conditions like MS and psoriasis.
Neuroprotective Effects: Investigated for its neuroprotective properties, potentially beneficial in neurodegenerative diseases beyond MS.
Oxidative Stress Reduction: DMF is known to reduce oxidative stress, which is a factor in the pathology of several chronic diseases.
Immunomodulatory Effects: Acts as an immunomodulator, altering the immune response, which is key in its effectiveness in autoimmune conditions like MS.
Research in Other Autoimmune Diseases: Being studied for potential use in other autoimmune diseases due to its immunomodulatory and anti-inflammatory properties.
Potential in Fibrotic Diseases: Early research suggests possible applications in treating fibrotic diseases due to its effects on certain pathways involved in fibrosis.
Antioxidant Properties: DMF has antioxidant properties, which contribute to its therapeutic effects in inflammatory and autoimmune diseases.