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Product Name:
Magnesium Bisglycinate
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Molecular Formula:
C4H8MgN2O4
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Molecular Weight:
172.42 g/mol
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CAS No.:
14783-68-7
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HSN Code:
29224990
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CID Code:
84645
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Shelf Life:
3 years
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DrugBank ID
DB11189
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ChemSpider ID
76358
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UNII No.
IFN18A4Y6B
- USP
- IUPAC Names
- Synonyms
USP of Magnesium Bisglycinate
- The chelation of magnesium with glycine improves its solubility in aqueous solutions. This increased solubility facilitates its absorption from the gastrointestinal tract.
- Potential synergistic effects with glycine
- The glycine molecules act as carriers, aiding in the transport of magnesium across the intestinal epithelium leading to Improved absorption
- Reduced gastrointestinal side effects
- This chelated form of magnesium is better tolerated
IUPAC Names of Magnesium Bisglycinate
- Magnesium diglycinate
- Magnesium bis(aminoacetate)
Synonyms of Magnesium Bisglycinate
- bis(glycinato)magnesium
- magnesium bis(glycinate)
- magnesium diglycinate
- magnesium 2-aminoacetate
- Magnesium Glycinate
- Bis(glycinato-N,O)magnesium
- Magnesium diglycinate
- magnesium;2-aminoacetate
- Magnesium glycinate
- [(2-aminoacetyl)oxy]magnesio 2-aminoacetate
- magnesium2-aminoacetate
- Glycine, magnesuim salt
- Magnesium 2-Aminoacetate xH2O
- Magnesium Glycinate [WHO-DD]
- Magnesium,bis(glycinato)- (6CI,7CI,8CI)
Description of Magnesium Bisglycinate
Magnesium bisglycinate is a fully reacted amino acid chelate in which one magnesium ion is bound to two glycine molecules. WBCIL’s magnesium bisglycinate is manufactured as a pharmaceutical-grade bulk API and nutraceutical raw material, available in powder and fine-granule forms for nutraceutical, pharmaceutical, functional food, and contract manufacturing applications. Supplied as bulk magnesium bisglycinate wholesale to brands and OEM manufacturers in 30+ countries under WHO-GMP-certified, HPLC- and FTIR-verified batch conditions.
WBCIL’s magnesium bisglycinate delivers 12–14% elemental magnesium, which is the confirmed range for a fully reacted, unbuffered chelate. This specification verifies that two glycine ligands have completely occupied all coordination sites on the magnesium ion. WBCIL additionally verifies chelation integrity using FTIR and ¹H NMR analysis on every commercial batch. Full documentation is available alongside the batch-specific CoA on request.
Available Forms
Supplied as bulk powder, fine granules, and DC-grade for direct compression tabletting. Buffered grade is available upon request for OEM formulations that require higher elemental yield—minimum order: 25 kg, scaling to metric-ton wholesale quantities with consistent CoA from batch to batch.
Application of Magnesium Bisglycinate
- Sleep & Neurological Support: High-absorption magnesium bisglycinate supports GABA receptor modulation and neurological relaxation at clinically meaningful doses. The glycine co-ligand provides inhibitory neurotransmitter activity — making it the preferred pharmaceutical sleep formulation ingredient.
- Muscle Function & Recovery: Used in oral formulations to prevent muscle cramps, support post-surgical recovery, and provide neuromuscular support. Superior GI tolerability allows full therapeutic doses without the laxative effect of magnesium oxide or citrate.
- Cardiovascular & Metabolic Support: Magnesium participates in 300+ enzymatic reactions, including ATP synthesis, glucose metabolism, and vascular regulation. Chelated bisglycinate delivers superior bioavailability at lower elemental doses than inorganic forms.
- Women’s Health & Prenatal: Used in prenatal vitamins and PMS-relief formulations where GI sensitivity limits the use of inorganic magnesium. Bisglycinate’s tolerability profile is the primary criterion for formulation selection.
- Bone Health: Chelated bisglycinate is incorporated into premium bone health formulations alongside Vitamin D3 and Vitamin K2. Enhanced absorption and GI tolerability make it the preferred chelated mineral for this application.
- Sleep & Stress Supplements: Magnesium bisglycinate combined with L-theanine or ashwagandha in capsule, sachet, and stick-pack formats. Targets sleep onset, stress resilience, and cortisol modulation for long-term supply agreements with wellness brands.
- Sports Recovery & Performance: Used in post-workout recovery blends and creatine co-formulations to prevent cramping and replenish magnesium lost during exercise. Compatible with direct-compression tabletting and beverage formats.
- Functional Beverages: High water solubility makes WBCIL’s chelated magnesium bisglycinate compatible with clear RTD formats and effervescent sachets. No sedimentation or chalky mouthfeel, a key formulation advantage over inorganic salts.
- Women’s Wellness Supplements: Used in prenatal vitamins and bone density formulations for women over 40. GI tolerability, clean-label status, non-GMO status, and allergen-free status are the primary selection criteria.
- Healthy Ageing & Cognitive Support: Included in premium ageing stacks alongside CoQ10 and Vitamin D. Magnesium’s role in mitochondrial ATP synthesis supports the category rationale for high-absorption chelated formats
- Veterinary Health: Used in equine and companion animal mineral supplements targeting muscle function, stress response, and bone density, where chelated forms outperform inorganic salts in palatability and absorption efficiency.
- Use as a reference in quality control (gravimetric/ICP-OES methodologies).
- Development of chelated matrices in research into new amino acid complexes.
Chelation Science & Delivery Mechanism
WBCIL’s process produces a fully reacted chelate — every magnesium ion bonded to two glycine ligands via coordinate covalent bonds. The stable heterocyclic ring is absorbed intact via peptide transport channels in the small intestinal epithelium.
Chelation Architecture
The glycine-magnesium-glycine ring shields the magnesium ion from stomach acid, phytates, and competing divalent cations (Ca²⁺, Zn²⁺, Fe²⁺) that occupy DMT-1 absorption sites. This protection is absent in oxide-buffered blends. The gut recognises the chelate as an amino acid dipeptide — not an inorganic mineral.
Absorption Mechanism
The chelate enters the enterocyte via PepT1 and amino acid transporter channels — a saturation-independent, high-capacity pathway. It does not draw osmotic water into the intestinal lumen. This eliminates the laxative effect that limits therapeutic dosing with magnesium oxide, sulphate, or carbonate.
Analytical Compliance
Chelation integrity confirmed by FTIR and ¹H NMR per batch. Elemental magnesium by ICP-OES. Heavy metals panel to USP <232>. Microbiology to USP <61>/<62>. Moisture by Karl Fischer. Full ICH Q1A/Q1B stability data. CoA per batch with batch number, manufacturing date, and retest date—compliant with full regulatory dossier standards for FDA, EMA, CDSCO, and FSSAI.
Magnesium Bisglycinate vs Other Magnesium Forms
| Parameter | Magnesium Bisglycinate (WBCIL) | Magnesium Glycinate Blend (Buffered) |
|---|---|---|
| Elemental Mg Content | 12-14% (fully reacted) | 15-20% (oxide-buffered) |
| Absorption Mechanism | Peptide transport (PepT1), saturation-independent | Partial peptide transport (unreacted fraction uses DMT-1) |
| Bioavailability | High, chelate absorbed intact | Variable — depends on the actual chelation ratio |
| Chelation Verification | FTIR + ¹H NMR per batch | Not verifiable by standard ICP-OES |
| GI Tolerability | Excellent, no osmotic load, no laxative effect | A moderate oxide fraction causes GI discomfort |
| RTD Beverage Compatible | Yes, freely soluble | Partially |
| Clean Label | Yes, non-GMO, allergen-free | Requires disclosure of oxide fraction |
| Pharmacopeia Status | Food supplement grade, not currently listed in EP or USP | Not listed |
OEM, Private Label & Bulk Ingredient Supply
WBCIL is a GMP-certified supplier and contract manufacturer of bulk magnesium bisglycinate, trusted by 4,000+ clients across 30+ countries. Pharmaceutical-grade wholesale supply for nutraceutical OEM brands, contract formulators, and private-label buyers globally.
Contract Manufacturing
End-to-end magnesium bisglycinate contract manufacturing with batch CoA, ICH stability data, FTIR and ¹H NMR chelation verification, and ICP-OES elemental analysis. Custom particle size, granulation, and co-processing with other actives are available for long-term supply agreements.
Private Labelling in 30+ Countries
Available as private-label magnesium bisglycinate with flexible MOQ. Custom packaging, 25 kg multi-layer bags with PE liner or fibre drums, with full regulatory documentation across US, EU, UK, GCC, ASEAN, and South Asian markets.
Bulk Ingredient Supply
GMP-certified magnesium bisglycinate bulk supplier, available in powder and granule forms in 25 kg moisture-resistant multi-layer bags or fibre drums. No cold-chain requirement — ambient storage throughout transit. Full CoA, MSDS, TDS, and stability data with every shipment.
Engineering Precision in WBCIL’s Chelated Mineral Systems
| Parameter | WBCIL Magnesium Bisglycinate | Commodity / Buffered Bisglycinate |
|---|---|---|
| Stabilising Agent | Citric acid during processing, fully disclosed, no residual active | Often undisclosed — impacts stability and label transparency |
| Regulatory Dossier | FDA, EMA, CDSCO, FSSAI-ready documentation supplied with the first order | Typically COA only |
| Documentation | FTIR, ¹H NMR, ICP-OES, heavy metals, microbiology, CoA per batch | Elemental potency only, chelation integrity unverified |
| Manufacturing Process | Patented green chelation process — no synthetic solvents, no high-temperature processing | Conventional, heat- or solvent-based processing degrades glycine coordination |
| Particle Size Control | Controlled distribution by laser diffraction per batch, powder and granule grades | Inconsistent, broad distribution, poor tabletting performance |
Sourcing Magnesium Bisglycinate from WBCIL
- Manufacturing Legacy: 64+ years of pharmaceutical API and chelated mineral manufacturing across India’s most regulated facilities.
- Patented Science: 17 active patents, including a proprietary green chelation process — no solvents, no high-temperature processing, full glycine coordination integrity.
- Analytical Rigour: Every batch is verified by FTIR and ¹H NMR, the only methods distinguishing fully reacted bisglycinate from oxide-buffered blends. Most suppliers verify elemental magnesium only.
- Global Reach: 4,000+ clients, nutraceutical OEM manufacturers, pharmaceutical formulators, contract manufacturers, and private label brands across 30+ countries.
- Award Recognised: National IP Award 2024, India’s Top MSME for Patent Filing and Commercialisation, Ministry of Commerce & Industry.
- Certified Compliance: WHO-GMP, cGMP, ISO, HACCP, FSSAI certified. US FDA guideline-compliant with full international regulatory dossier support.
Both names refer to the same compound, C₄H₈MgN₂O₄, CAS 14783-68-7. The critical variable is whether the product is fully reacted (12–14% elemental Mg) or oxide-buffered (>16% elemental Mg). WBCIL supplies only the fully reacted, unbuffered chelated form.
ICP-OES alone cannot distinguish a fully reacted chelate from an oxide-buffered blend. Only FTIR and ¹H NMR confirm the integrity of the actual chelation. WBCIL provides both with every commercial batch CoA — request this verified documentation from any magnesium bisglycinate supplier before procurement.
Bulk powder and fine granules from 25 kg to metric-ton scale—DC-grade and buffered grade available for OEM tabletting. Private label, custom particle size, co-processing, and long-term supply agreements are supported. Export to 30+ countries with full regulatory documentation.
Yes. WHO-GMP and cGMP-certified, with ICH Q1A/Q1B stability data, FTIR chelation verification, ICP-OES elemental analysis, and USP <232> heavy-metal testing per batch. Dossiers prepared to FDA, EMA, CDSCO, and FSSAI standards.
Yes. Non-GMO raw materials, free from 14 major EU allergens, no synthetic solvents. Halal and Kosher certification available on request. NSF and Informed Choice-ready documentation is available for brands requiring third-party tested ingredient verification.
