-
Product Name:
Ferrous Bisglycinate
-
Molecular Formula:
C4H8FeN2O4
-
Molecular Weight:
203.96 g/mol
-
CAS No.:
20150-34-9
-
HSN Code:
29224910
-
CID Code:
9837124
-
Shelf Life:
3 years - 20°C powder
-
DrugBank ID
DB11210
-
ChemSpider ID
8012845
-
UNII No.
SFW1D987QV
- USP
- IUPAC Names
- Synonyms
- MSDS
USP of Ferrous Bisglycinate
- Ferrous bisglycinate unlocks superior iron absorption since it is chelated.
- Have better patient compliance because of fewer gastrointestinal tract side effects.
- Experience better iron supplementation.
- delivery for body’s needs.
IUPAC Names of Ferrous Bisglycinate
2-aminoacetate;iron(2+)
Synonyms of Ferrous Bisglycinate
- Ferrous Bisglycinate
- Iron glycinate
- iron trisglycinate
- 2-aminoacetate;iron(2+)
- Iron Bis-glycinate
- Iron(II) glycinate
- Ferrousbisglycinate
- Iron, bis(glycinato-kappaN,kappaO)-
- Ferrous Glycinate
- Bis(glycinato)iron
- Iron bis-glycinate chelate
- lambda2-iron(2+) ion bis(2-aminoacetate)
- bis(glycinato-.kappa.n,.kappa.o)iron
MSDS of Ferrous Bisglycinate
Download MSDS PDF- APPEARANCE: Free flowing, light to dark greenish powder with occasional friable lumps.
- CAUTION: None
- TARGET ORGANS: None
- POTENTIAL HEALTH EFFECT (EYE, SKIN & INHALATION): Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation
- CHRONIC EXPOSURE: No known significant effects or critical hazards
- INHALATION: Move exposed person to fresh air. If not breathing, seek immediate medical attention. If breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel and seek medical attention.
- INGESTION: Vomiting caused by local irritant and astringent action of ionic Ferrous on stomach and bowel. IF SWALLOWED and victim is CONSCIOUS, have victim drink water or milk or induce vomiting.
- SKIN CONTACT: Irritant, wash with soap and water. Cover the irritating skin with an emollient. Get medical attention if irritation develops. Cold water may be used.
- EYE CONTACT: Conjunctivitis and edema of eyelids. Hold eyelids open and flush with plenty of water. Cold water may be used. Get medical attention if irritation occurs.
- ENGINEERING CONTROLS: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne Contaminants below the exposure limit.
- PERSONAL PROTECTION: Safety glasses, Lab Coat, Dust respirator, be sure to use an approved / certified respirator or equivalent, Gloves.
- PERSONAL PROTECTION IN CASE OF A LARGE SPILL: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self-contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.
- EXPOSURE LIMITS: Consult local authorities for acceptable exposure limits.
- Appearance form: Free flowing, light to dark greenish powder, with occasional friable lumps, very hygroscopic.
- Color: Light to dark greenish.
- Odour: Odorless
- Solubility: Soluble in water.
Description of Ferrous Bisglycinate
Ferrous bisglycinate, a well-tolerated iron supplement, boasts unique physical and chemical properties. It is light to dark greenish powder with occasional friable lumps and virtually no odor. Interestingly, this powder is non-hygroscopic, meaning it won’t readily absorb moisture from the air, enhancing its stability. On touch, ferrous bisglycinate has a slightly gritty texture due to its crystalline structure. Delving deeper, science reveals ferrous bisglycinate’s fascinating chemical makeup. It’s classified as a chelate, where two glycine molecules (the simplest amino acid) bond with a central ferrous iron (Fe+2) ion.
This bond creates a ring structure, improving iron’s bioavailability and reducing potential stomach upset compared to other iron supplements [1]. The chemical formula for ferrous bisglycinate is C₄H₈FeN₂O₄, offering a glimpse into its atomic composition. With its distinct properties, ferrous bisglycinate stands out as a valuable form of iron for dietary supplementation. As a leading API manufacturer, WBCIL prioritizes strict CGMP and ISO quality control measures throughout the production process.We offer a completely chelated structure confirmed by FTIR test. The prolonged experience from 1962 ensures consistent potency, purity, and safety in every dose of WBCIL’s ferrous bisglycinate.
Application of Ferrous Bisglycinate
Pharmaceutical Industry
- Iron Supplementation: Used in oral supplements to treat and prevent iron deficiency anemia, offering high bioavailability and fewer gastrointestinal side effects compared to other iron salts.
- Pregnancy: Recommended for pregnant women to prevent and treat iron deficiency anemia, providing a safe and effective option for maintaining adequate iron levels.
- Pediatric Supplements: Included in formulations for children to address iron deficiency, ensuring optimal growth and development.
Food and Beverage Industry
Fortification: Added to food and beverage products to enhance their iron content, especially in products aimed at populations prone to iron deficiency, such as infants, children, and women of childbearing age.
Sports Nutrition
Athlete Supplements: Used in supplements for athletes to support optimal iron levels, crucial for maintaining endurance, energy, and overall performance.
Veterinary Medicine
Animal Health: Employed in veterinary supplements to treat and prevent iron deficiency anemia in pets and livestock, improving their overall health and productivity.
Research and Development
Clinical Studies: Utilized in clinical trials to investigate its efficacy, safety, and advantages over other iron supplements in different patient populations.
Geriatrics
Elderly Care: Used in supplements for the elderly to address iron deficiency, offering a highly absorbable and gentle option for those with sensitive digestive systems.
Gastroenterology
IBD Management: Beneficial for patients with inflammatory bowel disease (IBD) as it provides iron supplementation with minimal gastrointestinal side effects, making it suitable for long-term use.
Women’s Health
Menstruation: Recommended for women with heavy menstrual bleeding to prevent and treat iron deficiency anemia, ensuring adequate iron levels and overall well-being.
Medical uses/benefits of Ferrous Bisglycinate
- Treatment in Inflammatory Bowel Disease (IBD): Ferrous bisglycinate is beneficial in various medical issues as its chelated form. It is less likely to react with the inflamed gastrointestinal lining and ensure better absorption and fewer side effects. Patients with IBD often suffer from iron deficiency due to chronic inflammation and impaired iron absorption.
- Improvement in Hemoglobin Levels: Regular supplementation can effectively raise hemoglobin levels, alleviating symptoms such as fatigue, weakness, and pallor associated with anemia.
- Chronic Kidney Disease (CKD): Ferrous bisglycinate is also used in patients with chronic kidney disease (CKD) who are non-dialysis dependent.
- Non-Dialysis Dependent CKD: Patients with CKD often develop anemia due to reduced erythropoietin production and iron deficiency. It helps manage this anemia by improving iron stores and supporting red blood cell production.
- Reduced Gastrointestinal Side Effects: Traditional iron supplements often cause side effects such as nausea, constipation, and abdominal pain. Ferrous bisglycinate is better tolerated, making it easier for patients to adhere to their supplementation regimen.
- This iron chelate allows for superior absorption of iron in the gastrointestinal tract compared to other iron supplements.
- High Bioavailability: The chelated nature of this API ensures that iron is efficiently absorbed by the intestinal lining. It also reduces the amount of unabsorbed iron that can cause gastrointestinal discomfort.
Dosages of Ferrous Bisglyciate (capsules)
- Adults (General) and pregnant woman :30 to 60 mg of elemental iron per day
- Children (Ages 4-13): 20 to 40 mg of elemental iron per day
- Athletes: 20 to 30 mg of elemental iron per day
Side effects:
Ferrous Bisglycinate may cause various side effects if not taken as advised. Here are the key side effects:
- Constipation
- Nausea
- Diarrhea
- Stomach Pain
- Vomiting
- Dark Stools
- Metallic Taste
Surpassing competitors, West Bengal Chemical Industries Limited reigns supreme as India’s leading manufacturer of high-quality ferrous bisglycinate.
The raw materials used in the production of ferrous bisglycinate are iron and glycine. Specifically, ferrous bisglycinate is a chelated form of iron, where iron is bound to the amino acid glycine. This chelation helps enhance the absorption and bioavailability of iron in the body.
Ferrous bisglycinate is crafted through a chemical reaction between ferrous iron (Fe+2) and the amino acid glycine (H2NCH2COOH). This process, known as chelation, involves ferrous iron bonding with two glycine molecules. Typically, it’s achieved in a controlled aqueous environment with precise temperature and concentration parameters. The resulting compound is a stable and well-absorbed form of iron, making it a valuable dietary supplement.
Ferrous bisglycinate offers better patient compliance due to fewer gastrointestinal side effects. It enhances iron absorption, improves iron storage, and increases hemoglobin levels more effectively than traditional iron salts.
The best form of ferrous bisglycinate can depend on individual needs and preferences, but some commonly recommended forms include: Capsules, Tablets, Powder, Liquid and Gummies.
Yes, ferrous bisglycinate is considered a good form of iron supplement for several reasons:
- Enhanced Absorption
- Fewer Gastrointestinal Side Effects
- Better Tolerance
- Effective at Increasing Hemoglobin Levels
- Convenience
