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Optimizing Your Health: A Practical Guide to Magnesium Bisglycinate
Published on: May 18, 2024

Exploring Magnesium Bisglycinate for Optimal Health

Magnesium (Mg) plays a significant role in human body. It is an essential mineral that supports various functions involved in more than 200 reactions. This alkaline metal is the 12th element on the periodic table with atomic weight of 24.321.  Magnesium has silvery whitish appearance. 60% of our body’s magnesium is found in the bones. It helps to maintain bone density alongside calcium and Vitamin D. Mg helps in heart rhythm, muscle contraction and ATP production.1 2

Importance of Choosing the Right Magnesium Supplement

Choosing the right Magnesium supplement is important because there are various forms available in the market. There are some parameters to look into including bioavailability, potential benefits and side effects.3 West Bengal Chemical Industries Limited is one of the top Magnesium Bisglcinate manufacturers in India and we are proudly produce high quality magnesium Bisglycinate.

Understanding Different Forms of Magnesium

Overview of Various Magnesium Compounds

Magnesium is available in various compound forms. Each of the compounds carries specific characteristics, benefits and side effects. Here is a brief discussion:

  1. Magnesium Oxide: It contains a high percentage of elemental magnesium. The bioavailability is lower than Magnesium Citrate- 4% and it has antacid properties. It is often used to treat indigestion.
  2. Magnesium Citrate: This magnesium salt contains citric acid. It is mainly used to treat constipation and popular for its good absorption.
  3. Magnesium Chloride: MgCl2 or Magnesium Chloride salt is made up of two chloride ions. Its bioavailability is also high. It is mainly used for oral supplements.
  4. Magnesium Glycinate/ Bisglycinate: This magnesium chelate bound to the amino acid glycine.3 4
Exploring Magnesium Bisglycinate for Optimal Health and wellness

Factors Differentiating Magnesium Bisglycinate

There are various factors that differentiate magnesium bisglycinate from other magnesium minerals/salts including magnesium oxide, magnesium citrate, and magnesium chloride.
Magnesium bisglycinate is a chelated form of magnesium where the magnesium is bound to glycine [HO2CCH2NH2].5 6 7

Magnesium Type Composition/Description Bioavailability Primary Uses
Magnesium Oxide Contains a high percentage of elemental magnesium. Low Treating indigestion, antacid
Magnesium Citrate Magnesium salt contains citric acid. High Treating constipation
Magnesium Chloride (MgCl2) Made up of two chloride ions. High Used for oral supplements
Magnesium Glycinate/Bisglycinate Chelated form bound to the amino acid glycine (HO2CCH2NH2). High Various industrial uses

Importance of Bioavailability and Absorbability

While choosing pharmaceutical/nutraceutical supplements, understanding bioavailability and absorbability are two crucial factors. A supplement/medication will only take effect while absorbing by the body. So, bioavailability is a percentage to proven its benefits. It is a measure of how much supplement can be absorbed by the body. In a same way, absorbability means how quickly the supplement works.

Magnesium Bisglycinate: The Superior Choice

Magnesium bisglycinate is one of the high absorbable magnesium forms. Due to its glycine, it offers high bioavailability.

This chelate has superior bioavailability than other magnesium salts. For an example, unlike magnesium sulfate/oxide, this chelated mineral is not dependent on stomach acid absorption. It makes it unique and highly beneficial for individuals with reduced stomach acidity. Choosing magnesium bisglycinate produced by West Bengal Chemical Industries Limited can be significantly enhancing magnesium intake efficiency, supporting overall health and wellness.7 8 9

Enhanced Bioavailability Explained

Unlike other magnesium minerals/salts taken from inorganic sources, magnesium bisglycinate is made of organic compound like amino acids. This is the reason of bioavailability and efficiency. Research indicates that only about 4% of magnesium oxide is absorbed by the body, with the remaining 96% being excreted and not utilized.

Unlike magnesium oxide and magnesium citrate, Magnesium Bisglycinate is better absorbed that any other forms of magnesium. And again, it is all about its chelated structure that helps to increase the solubility.
Minimal Side Effects and Safety Profile

Generally the consumption level of magnesium among adults is 420 mg. Yet some magnesium supplements may cause diarrhoea and cramps. As per the study, magnesium bisglycinate is the safest option.

Benefits of Magnesium Bisglycinate

Health Benefits of Magnesium Bisglycinate

Promoting Heart Health

Magnesium plays an important role in heart health by helping to maintain a normal heart rhythm and supporting the contraction and relaxation of heart muscles. As per studies by Dr. DeSimone, it is a key electrolyte in the body and significant for proper homeostasis. As magnesium is involved transporting other electrolytes such as Caclium, potassium etc., it helps in heart rhythm. It also helps in producing ATP, the main source of energy for cellular activities. Regular intake of magnesium bisglycinate helps in the prevention of arrhythmias and cardiac dysfunction.7 8

Blood Pressure Regulation

Here is another key benefits of magnesium bisglycinate is to help regulating blood pressure. It acts as a natural calcium channel blocker that helps in relaxation and widens blood vessels. This relaxation improves blood flow and reduces the pressure within the vessles.

Alleviating Muscle Cramps and Enhancing Bone Health

Do you know Vitamin D and calcium supplements are not enough treating condition like Osteoporosis?

Magnesium bisglycinate helps in bone health. Magnesium has anti-inflammatory properties that help alleviating the discomfort related to muscle cramps. By supplementing with magnesium bisglycinate, one can help increase the magnesium levels and reduce the muscle cramps.9

Magnesium is essential for the synthesis of collagen that forms the structural framework of bones. It helps in maintaining bone strength and stamina.

Improving Exercise Performance and Stamina

Magnesium bisglycinate is the most absorbable magnesium salts and mostly popular for its great benefits in improving exercise performance and stamina.

Source of ATP:
Mg is crucial for ATP production. Adequate magnesium levels ensure that muscles have the energy required for sustained exercise.Magnesium helps in regulating muscle contractions by controlling calcium (Ca) influx into muscle cells. It prevents muscle fatigue and cramping during intense workout sessions.It also plays a huge role in protein synthesis that helps in muscle repairing and growth.

Supporting Blood Sugar Control and Insulin Sensitivity

Magnesium is involved in over 300 enzymatic reactions for human body. Adequate magnesium helps to maintain blood sugar by increase the activity of insulin.

It also helps improve insulin sensitivity, making it easier for cells to absorb glucose and lowers the blood sugar levels. Mg’s anti-inflammatory properties help reducing system in inflammation and promote better blood sugar control.

Facilitating Quality Sleep and Reducing Anxiety

Magnesium bisglycinate plays a critical role in the production and regulation of melatonin. This melatonin hormone is responsible for controlling the sleep-cycle. Adequate magnesium helps synchronize rhythms, prompting sleep. Beta cells in the pancreas are responsible for producing insulin. Magnesium supports the health and function of these cells, ensuring adequate insulin production in response to blood sugar levels.
Exploring Magnesium Bisglycinate for Optimal Health

Practical Considerations of Magnesium Bisglycinate and Usage Tips

Optimal Dosage Recommendations

The daily recommended intake of magnesium for adults [Male] is generally between 380-420 mg/day and 320 mg/day for female.12 For individuals looking to improve blood sugar control and insulin sensitivity, it’s important to consult with a healthcare provider for a personalized dosage recommendation.

Potential Interactions

Magnesium Bisglycinate is safe and well-tolerated but it is also important to be aware of potential interactions and precautions to ensure the effective uses.


Antibiotics: Magnesium can interfere with the absorption of certain antibiotics like tetracyclines and fluoroquinolones. To avoid this interaction, take magnesium supplements at least 2 hours before or 4-6 hours after these antibiotics.10

Diuretics: Some diuretics especially loop and thiazide diuretics, can increase the excretion of magnesium through urine, potentially leading to magnesium deficiency.

Precautions while taking Magnesium Bisgycinate

Kidney Disease: Impaired kidney function can lead to difficulty in excreting excess magnesium, increasing the risk of magnesium toxicity.

Heart Conditions: While magnesium is beneficial for heart health, excessive doses can affect heart rhythms, especially in individuals with preexisting heart conditions.

Pregnancy and Breastfeeding: Magnesium bisglycinate is generally considered safe during pregnancy and breastfeeding.10 11

Digestive Issues: High doses of magnesium can cause gastrointestinal symptoms such as diarrhea, nausea, and abdominal cramping. Starting with a lower dose and gradually increasing it can help mitigate these side effects.

Why choose as Magnesium Bisglycinate manufacturer in Indi Easily available at West Bengal Chemical Industries Limited

Experience the benefits of our scientifically formulated Magnesium Bisglycinate, designed for optimal absorption and efficacy at WBCIL. Our product ensures a smooth, side-effect-free experience. As one of India’s leading API manufacturers, we are dedicated to delivering products that meet the highest standards of purity and effectiveness. From enhancing muscle function and bone health to improving sleep quality and reducing anxiety, our Magnesium Bisglycinate caters to all your needs.


Magnesium bisglycinate stands out as a superior supplement choice for those seeking to enhance their overall health and wellness. Its role in regulating blood sugar levels, enhancing insulin sensitivity, and facilitating quality sleep further underscores its importance.

Choosing the right magnesium supplement is vital, and magnesium bisglycinate’s superior bioavailability and gentle impact on the digestive system make it an excellent option.  West Bengal Chemical Industries Limited (WBCIL), one of India’s top API manufacturers, ensures the highest standards of purity and effectiveness in their Magnesium Bisglycinate product.

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 75487596, Magnesium bisglycinate
  2. Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy.Nutrients. 2015;7(9):8199-8226. doi:10.3390/nu7095388
  3. Schwalfenberg GK, Genuis SJ. The importance of magnesium in clinical healthcare.Scientifica (Cairo). 2017;2017:4179326. doi:10.1155/2017/4179326
  4. Molinari C, Ruga S, Farghali M, et al. Preventing c2c12 muscular cells damage combining magnesium and potassium with vitamin D3 and curcumin.J Tradit Complement Med. 2021;11(6):532-544. doi:10.1016/j.jtcme.2021.05.003
  5. National Institutes of Health.
  6. Dalton LM, Ní Fhloinn DM, Gaydadzhieva GT, et al. Magnesium in pregnancy.Nutr Rev. 2016;74(9):549-557. doi:10.1093/nutrit/nuw018
  7. https://www.webmd.com/diet/supplement-guide-magnesium


Frequently Asked Questions on: Exploring Magnesium Bisglycinate for Optimal Health
Is magnesium bisglycinate the same as magnesium glycinate?

Yes, magnesium bisglycinate and magnesium glycinate are the same compound.

Who should consider taking magnesium bisglycinate?

Individuals with magnesium deficiency, those experiencing muscle cramps, people with heart health concerns, individuals with insomnia or anxiety, and those looking to improve exercise performance might benefit from magnesium bisglycinate.

Can I take magnesium bisglycinate with other medications?

Yes, but it’s important to be aware of potential interactions with antibiotics (e.g., tetracyclines, fluoroquinolones) and diuretics. Consult your healthcare provider for personalized advice.

What is magnesium bisglycinate good for?

Magnesium bisglycinate is good for improving sleep, reducing anxiety, relieving muscle cramps, and supporting overall muscle and nerve function.

Is magnesium bisglycinate useful for weight loss?

Magnesium bisglycinate is not specifically useful for weight loss.

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