Calcium Citrate Malate

A renowned calcium salt made of variable composition of citric acid and malic acid, Calcium Citrate Malate is a water-soluble composition, which means it can dissolve in water without the help of stomach acid. This formula is used in drugs for restoring calcium deficiency, weak bones, and decreased activity of the parathyroid gland.

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Molecular Formula – C16H14Ca4O19
Molecular Weight – 670 gm/mol
Melting Point – 40° C to 60° C.
CAS No. – 142606-53-9
Shelf Life – 36 months
Storage Advice – Store at cool, dry room temperature in an inert atmosphere away from sunlight.
Packing Size
HSN Code

Features – White Crystalline Powder, Colour – White to off-White, Odourless.
Solubility – Soluble in 0.5g/100 ml of water at 20°C
pH Range – 4.0 – 8.0
LOD (at 105° for 4 Hr) – 10.0% w/w – 13.0% w/w
Heavy Metals (as Lead) – NMT 10.0 ppm.
Assay (as calcium) – 20.0% w/w – 24.0% w/w
Bulk Density
Untapped – 0.50 -0.80 gm/ml
Tapped – 0.60 – 0.90 gm/ml

Drug Uses: Calcium Citrate Malate is popularly used to treat calcium deficiency in the blood.
It is also used in drugs used for calcium retention and bone accrual in adolescents and children.
Calcium Citrate Malate is also combined with Vitamin D tablets to lower the risk of bone fracture.
It is also used to prevent osteoporosis.
Calcium Citrate Malate is considered a great source of calcium for individuals with hypochlorhydia or achlorhydia.

Food: Calcium Citrate Malate is used as a source of calcium in beverages.

Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older

Abstract Background: Inadequate dietary intake of calcium and vitamin D may contribute to the high prevalence of osteoporosis among older persons. Methods: We studied the effects of three years of dietary supplementation with calcium and vitamin D on bone mineral...

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Comparative absorption of calcium sources and calcium citrate malate for the prevention of osteoporosis

Abstract Anthropologically speaking, humans were high consumers of calcium until the onset of the Agricultural Age, 10,000 years ago. Current calcium intake is one-quarter to one-third that of our evolutionary diet and, if we are genetically identical to the Late...

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The health benefits of calcium citrate malate: a review of the supporting science

Abstract There has been considerable investigation into the health benefits of calcium citrate malate (CCM) since it was first patented in the late 1980s. This chapter is a comprehensive summary of the supporting science and available evidence on the bioavailability...

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